Steroid 12-alpha-Hydroxylase

Medical Dictionary -> Steroid 12-alpha-Hydroxylase

Steroid 12-alpha-Hydroxylase


A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.


© MedicalDictionaryweb.com 2012 | Contact Us | Terms of Use | Teeth Whitening | Low Carb Foods and Diets