Persistent Hyperinsulinemia Hypoglycemia of Infancy

Medical Dictionary -> Persistent Hyperinsulinemia Hypoglycemia of Infancy

Persistent Hyperinsulinemia Hypoglycemia of Infancy


A form of nontransient HYPOGLYCEMIA, unique to infancy, due to autosomal recessive mutations of the sulfonylurea receptor gene on CHROMOSOME 11. Defects in the sulfonylurea receptors (ATP-BINDING CASSETTE TRANSPORTERS) on the PANCREATIC BETA CELLS prevent negative feedback of GLUCOSE-regulated INSULIN release thus resulting in HYPERINSULINEMIA. Clinical phenotype includes SEIZURES; COMA; and often large BIRTH WEIGHT for GESTATIONAL AGE.


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