Holocarboxylase Synthetase Deficiency

Medical Dictionary -> Holocarboxylase Synthetase Deficiency

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Holocarboxylase Synthetase Deficiency

The neonatal form of MULTIPLE CARBOXYLASE DEFICIENCY that is caused by a defect or deficiency in holocarboxylase synthetase. HLCS is the enzyme that covalently links biotin to the biotin dependent carboxylases (propionyl-CoA-carboxylase, pyruvate carboxylase, and beta-methylcrotonyl-CoA carboxylase).