Formate-Tetrahydrofolate Ligase

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Formate-Tetrahydrofolate Ligase


A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and TETRAHYDROFOLATE in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.

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