Colorectal Neoplasms, Hereditary Nonpolyposis

Medical Dictionary -> Colorectal Neoplasms, Hereditary Nonpolyposis

Colorectal Neoplasms, Hereditary Nonpolyposis


A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes.


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